Cellular stress response The integrated stress response is a cellular stress response conserved in eukaryotic cells that downregulates protein synthesis and upregulates specific genes in
2O2 by upregulating the Nox4-p22phox, making Nox4 a critical mediator of oncogenic Ras-induced DNA damage [ Significant studies have shown that ROS interacts with cellular
Using skin cells from adult siblings with schizophrenia and a genetic mutation linked to major mental illnesses, Johns Hopkins researchers have created induced pluripotent stem
Jones DP. Radical-free biology of oxidative stress. Am J Physiol Cell Physiol. 2008;4:C849–68. Halliwell B, Gutteridge J. Free radicals in biology and medicine. 4th ed.
There has been a growing interest in the potential of stem cell transplantation as therapy for pediatric brain injuries. Studies in pre-clinical models of pediatric
Loss of bladder control afflicts over 13 million Americans, some of whom receive collagen shots to add bulk to the bladder sphincter. But sometimes, the
Cancer cells rely on high levels of ER stress response to deal with misfolded proteins and rapid growth. Excessive and prolonged UPR activation has been
Summary Cell biologist Michael Overholtzer explains apoptosis, a form of programmed cell death that can lead to cancer when it doesn’t function properly. The death